| Thu, Dec 29 2011 | Buffalo Bills (6-9) Finish Regular Season Versus New England Patriots (12-3) |
| Thu, Dec 22 2011 | Buffalo Bills (5-9) Face Denver Broncos (8-6) |
| Thu, Dec 15 2011 | Buffalo Bills (5-8) Meet Miami Dolphins (4-9) |
| Thu, Dec 08 2011 | Buffalo Bills (5-7) Take On San Diego Chargers (5-7) |
| Thu, Dec 01 2011 | Buffalo Bills (5-6) Clash with Tennessee Titans (6-5) |
| Thu, Nov 24 2011 | Buffalo Bills (5-5) Face Tough Task Against New York Jets (5-5) |
| Thu, Nov 17 2011 | Buffalo Bills (5-4) Face Miami Dolphins (2-7) |
| Thu, Nov 10 2011 | Buffalo Bills (5-3) Take On Dallas Cowboys (4-4) |
| Thu, Nov 03 2011 | Buffalo Bills (5-2) Face New York Jets (4-3) |
| Fri, Oct 28 2011 | Buffalo Bills (4-2) Meet Washington Redskins (3-3) |
| Sun, Oct 16 2011 | Buffalo Bills (4-1) Take On New York Giants (3-2) |
| Sun, Oct 09 2011 | Buffalo Bills (3-1) Battle Philadelphia Eagles (1-3) |
| Sun, Oct 02 2011 | Buffalo Bills (3-0) Clash with Cincinnati Bengals (1-2) |
| Sun, Sep 25 2011 | Buffalo Bills (2-0) Play Underdog to New England Patriots (2-0) |
| Sun, Sep 18 2011 | Buffalo Bills (1-0) Meet Oakland Raiders (1-0) |
| Sun, Sep 11 2011 | Buffalo Bills Kick Off Season Versus Kansas City Chiefs |
| Sun, Jan 02 2011 | Buffalo Bills (4-11) and New York Jets (10-5) Close Out Regular Season |
| Sun, Dec 26 2010 | Buffalo Bills (4-10) Seek to Upend New England Patriots (12-2) |
| Sun, Dec 19 2010 | Buffalo Bills (3-10) Square Off Against Miami Dolphins (7-6) |
| Sun, Dec 12 2010 | Buffalo Bills (2-10) Clash with Cleveland Browns (5-7) |
| Sun, Dec 05 2010 | Buffalo Bills (2-9) Go Up Against Minnesota Vikings (4-7) |
| Sun, Nov 28 2010 | Buffalo Bills (2-8) Face Off Against Pittsburgh Steelers (7-3) |
| Sun, Nov 21 2010 | Buffalo Bills (1-8) Battle Cincinnati Bengals (2-7) |
| Sun, Nov 14 2010 | Buffalo Bills (0-8) Face Detroit Lions (2-6) |
| Sun, Nov 07 2010 | Buffalo Bills (0-7) Face Chicago Bears (4-3) |
| Sun, Oct 31 2010 | Buffalo Bills (0-6) Play Underdog Role Against Kansas City Chiefs (4-2) |
| Sun, Oct 24 2010 | Buffalo Bills (0-5) Seek to Upend Baltimore Ravens (4-2) |
| Sun, Oct 10 2010 | Buffalo Bills (0-4) Face Jacksonville Jaguars (2-2) |
| Sun, Oct 03 2010 | Buffalo Bills (0-3) Square Off Against New York Jets (2-1) |
| Sun, Sep 26 2010 | Buffalo Bills (0-2) Look to Upset Favorite New England Patriots (1-1) |
